In 2022, the Royal Swedish Academy of Sciences awarded the Nobel Prize in Chemistry for the development of click chemistry and bioorthogonal chemistry. In the recently published Perspective in the journal Chemical Science, IOM scientists present their personal opinions and backgrounds on this highly significant topic discussing the main challenges and identifying possible solutions to develop bioorthogonal approaches tailored to redox-, spin-, and photo-active polyoxometalates (molecular metal oxides) and to improve polyoxometalate biological tolerance. Advances in bioorthogonal polyoxometalate chemistry will open exciting opportunities for the controlled use of these stimuli-responsive nanoassemblies in biomedical applications as well as catalysis and electronics.

S.K. Petrovskii, E.V. Grachova, K.Yu. Monakhov
Bioorthogonal chemistry of polyoxometalates challenges and prospects
Chem. Sci. 15 (2024) 4202-4221
DOI: 10.1039/D3SC06284H